The win solidified the Leafs hold on first place in the Northern Division as they now have 49 points (23-10-3), 3 more than second place Jets with 46.
Mitch Marner had a pair of assists for Toronto, who kicked off a four game western road trip with a win.
Jack Campbell turned aside 26 shots for the Maple Leafs to win his 7th game of the season.
Campbell started his fourth game in the last five as starting goaltender Frederik Andersen remains in Toronto to have his lower body injury further evaluated.
Mitch Marner had a pair of assists.
The Leafs power play went 0-for-5 in the game but did manage to score a shorthanded goal.
Josh Morrissey scored the lone goal on the night for the Jets.
Connor Hellebuyck made 23 saves for Winnipeg, who dropped to 22-13-2.
Auston Matthews scored 4:40 into the first, snapping a rebound off a Zach Hyman backhand past Hellebuyck to make it 1-0 Toronto.
The goal was his 24th of the season.
Zack Hyman scored at 10:47 when he knocked the puck past Hellebuyck after Auston Matthews hit the post with a wrister and the disc dropped behind the goaltender's right leg.
The goal was his 11th of the season.
The Jets challenged the goal citing goaltender interference but the goal was allowed to stand after review.
With TJ Brodie off for four minutes for high sticking Paul Stastny, Alexander Kerfoot scored on a shorthanded breakaway 16:40 into the second period to make it 3-0 Maple Leafs after Jet defenceman Josh Morrissey had attempted to keep a puck in the Toronto end only to have it bounce off of Ilya Mikheyev and land right in Kerfoot's path.
Kerfoot skated in and put the puck right under the crossbar to score his 6th of the season.
Josh Morrissey got the Jets on the board 35 seconds later with a power play marker when his slapshot from the point beat Toronto netminder Jack Campbell to make it 3-1.
The goal was his 2nd of the season.
There was no scoring in the third period.
The two clubs face each other again Friday night in Winnipeg.
SHOTS-TORONTO 26 WINNIPEG 27
Jets captain Blake Wheeler did not return to the game after the first period.
Winnipeg's Paul Stastny appeared to lose a tooth in the second period after being struck with a high stick by Maple Leafs defenceman TJ Brodie.
The contest marked Winnipeg goaltender Connor Hellebuyck's 299th career game.