Walker Duehr scored the other Calgary goal.
Dustin Wolf made 24 saves for the Wranglers, who moved to 6-5-0-0.
Jeff Malott and Evan Polei scored for Manitoba.
Oskari Salminen turned aside 22 shots for the Moose, who dropped to 6-3-1-0.
Cole Schwindnt gave Calgary the lead on the power play when he took a feed off the rush from Jakob Pelltier in the high slot before moving in and beating Salminen high blocker side to put Calgary up 1-0 at 9:21.
Schwidnt knotted his second power play marker of the night 1:46 into the second period when he corralled a loose puck in the slot Jajob Pelltier redirected right onto his stick two feet out from the net.
Schwindt snapped it past Salminen to make it 2-0 Wranglers.
The goal was his 2nd of the season.
Walker Duehr scored 2:13 into the third, walking around Moose defenceman Simon Lundmark before lifting a backhand past Salminen to make it 3-0 Wranglers.
The goal was his 3rd of the season.
Jeff Malott replied for Manitoba just over two minutes later when he drove the net and converted a Kevin Stenlund feed from close in to make it 3-1 at 4:14.
The goal was his 3rd of the season.
Evan Polei tipped a Ville Heinola point shot past Wolf at 5:39 to pull Manitoba within a goal.
Josh Brook appeared to score Calgary's fourth goal of the night when he fired a wrister from the high slot past Salminen during a goalmouth scramble but it was waved off by referee Stephen Hiff for goaltender interference at 9:49.
Moose Head Coach Mark Morrison pulled Salminen in favor of an extra attacker with just over two minutes left in regulation but Manitoba was unable to score.
SHOTS-CALGARY 25 MANITOBA 26
ATTENDANCE-4092
