The win was their first of the season.
Nick Swaney, Steven Fogarty and Adam Beckett scored the other Wild goals.
Joe Hicketts had a pair of assists.
Zane McIntyre turned aside 33 shots for Iowa, who won their first game of the season (1-2-0-2).
Kevin Stenlund, Jansen Harkins scored for the Moose.
Oskari Salminen made 15 saves for Manitoba, who saw their four game winning streak snapped as they dropped to 4-1-1.
Nick Swaney got Iowa on the board 4:52 into the contest when he broke in alone on Moose goaltender Oskari Salminen and handcuffed him with a high shot which Salminen managed to get a piece of.
The goal was his 3rd of the season.
Kevin Stenlund tied the contest on the power play when he caught the rebound off a shot off the cross bar and shot the puck into a wide open net at 7:33.
With Manitoba enjoying a two-man advantage Ville Hienola cranked a shot off the cross bar with the puck ending up right on Kevin Stenlund's stick.
Stenlund shot the puck into a wide open net to make it 1-1.
The Wild took the lead 5:21 into the second when defenceman Joe Hicketts found Steven Fogarty and hit him with a centering pass from the right faceoff circle. Fogarty got his stick down and redirected the disc past Salminen to make it 2-1 Iowa.
The goal was his 1st of the season.
With Jansen Harkins off for slashing, the Wild took a two-goal lead at 9:31 of the second when Adam Beckman hit Sammy Walker in the high slot with a crisp pass and the Iowa forward made no mistake, drifting a high wrister past Salminen, beating the Manitoba goaltender glove side to make it 3-1.
The goal was his 3rd of the season.
The Wild power play struck again at 13:55 when Sammy Walker tipped a puck off a Mitchell Chaffee shot from the top of the faceoff circle past Salminen to make it 4-1.
Jansen Harkins cut the Iowa lead in half 6:20 into the third when he took advantage of a Daemon Hunt miscue behind the Iowa net.
Hunt lost control of the puck and Harkins simply took a stride and tucked the disc between McIntryre's pads to make it 4-2.
The goal was his 5th of the season.
Adam Beckman added an empty netter to seal the win for the Wild.
SHOTS-IOWA 20 WINNIPEG 35
ATTENDANCE-2483