Detroit has won four of their last five contests.
Lukas Raymond had a goal and an assist.
Alex DeBrincat also scored for the Red Wings.
John Gibson made 25 saves for Detroit, who moved to 32-6-5.
Cole Koepke scored the lone goal for the Jets, who have lost four of their last five games after winning four in a row.
Connor Hellebuyck stopped 26 shots for Winnipeg, who dropped to 20-24-7.
There was no scoring in the first period.
Cole Koepke opened the scoring just over halfway into the second when he sprawled and knocked a loose disc past John Gibson to give the Jets a 1-0 lead at 10:08.
The goal was his 4th of the season.
J.T. Compher tied it 15:50 into the second when he lifted a backhand past Hellebuyck as he was falling to the ice during a goalmouth scramble.
Compher scored the go-ahead goal 1:43 into the third when he drove the net hard and re-directed a hard pass from Emmit Finnie at the edge of the crease past Hellebuyck to make it 2-1 Red Wings.
The goal was his 8th of the season.
Lucas Raymond gave Detroit a two-goal cushion 8:11 into the third when he cut hard to the net, forcing Hellebuyck to make a save in tight before the puck deflected upward and arched into the Winnipeg goal.
The play was reviewed for a high stick by Marco Kasper but it was allowed to stand.
Alex DeBrincat added an empty netter with 1:49 remaining in regulation to seal the win for the Red Wings.
Marco Kasper added to the lead to make it 5-1, beating Hellebuyck with a wrister to make it 5-1 Detroit with 1:17 remaining.
SHOTS-DETROIT 31WINNIPEG 26
ATTENDANCE-15,225
